Both safes share the same security spec — B-rated construction, LaGard 702 series time-delay lock, 1″ stainless steel locking bolt, A36 resistant plate, 29 codes (1 manager + 28 user). The substantive difference is configuration: A-3524-R4 carries an integrated methadone bottle holder built into the drawer space, and ships in a white powder-coated finish at slightly different dimensions (35″ × 24″ × 22″ versus 34″ × 24″ × 20″ on the StrongBox). The Advance Series is intended for community pharmacies running methadone or multi-program dispensing where the methadone holder removes the need for a separate accessory. If you're running standard Schedule II dispensing without methadone, the StrongBox B-3424-R4 covers the use case at $100 more and is the simpler choice.